Mutations in the p53 tumor suppressor gene are frequently observed in colon, lung, breast, stomach and many other neoplasms, suggesting that these mutations are critical events in the maligant transformation. PCNA(proliferating cell nuclear
antigen),
known as a 36 kD nuclear proteinassociated with a cell cycle, reported as a useful tool to study cell kinetic information with histologically based tumor classification. We studied to see the correlation between p53 expression and PCNA expression
of the
colorectal carcinoma and adenoma. We examined the presence of mutant p53 gene, PCNA expression in 47 cases of colorectal carcinoma, adenoma by using immunohistochemical staining. Although it seems that p53 immunoreactivity and PCNA expression was
not
related with cellular differation and lymph node metastasis, colon cancer group with high expression of p53 showed increment of PCNA expression. (Korean J Gastroenterol 1994 ; 26 : 647-654)
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